Introduction
to Protein StructureIntroduction
to Protein Structure
Overall Charge on a Peptide -- Example 1
Valinylisoleucylleucylmethionine
(Val-Ile-Leu-Met; VILM)
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The only ionizable groups in this peptides are the amino group (pka ~ 9) and the carboxyl group (pKa ~ 3) at each end of the molecule.
Thus, the net charge on this peptide at three different pH's ( 2, 7 and 11) is as follows:
| Charge on Functional Group | ||||
| pH | N-terminus | C-terminus | Net Charge | |
| 2.0 | 1+ | 0 | 1+ | |
| 7.0 | 1+ | 1- | 0 | |
| 11.0 | 0 | 1- | 1- | |
Copyright © 1998, 1999, 2007 by Frank R. Gorga; Page maintained by F.R. Gorga; Last updated: 12-Mar-2007