Introduction to Protein Structure

Acknowlegements

• Financial support for this project was provided by the Courseware Development Project at Bridgewater State College.

• I would like to thank Drs. Dabney Dixon and Don Harden of the GLACTONE project at Georgia State University for permission to use their pdb files and Dr. Charles Gasser at the University of California, Davis for permission to link to his web site.

• The files containing structural data for the protein structures used in this presentation were obtained from the Protein Databank.

• Lysozyme is entry 1HEL. Original reference:  K.P. Wilson, B.A. Malcolm, B.W. Matthews, Structural and Thermodynamic Analysis of Compensating Mutations within the Core of Chicken Egg White Lysozyme, J. Biol. Chem. 267:10842 (1992) (medline)

• Triosephosphate isomerase (TPI) is adapted from entry 1TIM. Original reference: D.W. Banner, A.C. Bloomer ,G.A. Petsko, D.C. Phillips,   I.A. Wilson, Atomic Coordinates for Triose Phosphate Isomerase from Chicken Muscle, Biochem. Biophys. Res. Comm. 72:146 (1976) (medline)

• Hemoglobin is entry 1HBH. Original reference: Ito, N., Komiyama, N. H., Fermi, G.: Structure of Deoxyhaemoglobin of the Antarctic Fish Pagothenia Bernacchii with an Analysis of the Structural Basis of the Root Effect by Comparison of the Liganded and Unliganded Haemoglobin Structures. J.Mol.Biol. 250:648 (1995) (medline)

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