org_logo.gif (2469 bytes) First Year Seminar in Chemistry (CHEM 199)

The Science of Pharmaceutical Development

Instructor: Frank R. Gorga, Ph.D.

 

Please note:

This material is from the Fall 2007 semester.
It will not be updated again until I next teach this course.
Course Documents
Syllabus
Periodic Table (pdf file)
Assignment #1 (pdf file)
Assignment #2 (pdf file)
Assignment #3 (pdf file) -- see info in notes from Lecture 30
Lecture 1
Lecture 2
Lecture 3 (Wed., 12 Sept.)
Lecture 4 (Fri., 14 Sept.)
Lecture 5 (Mon., 17 Sept.)
Lecture 6 (Fri., 21 Sept.)
Lecture 7 (Mon, 24 Sept.) -- Practice Molecules "Solved"
Lecture 8 (Wed, 26 Sept.)
Answers to Quiz 1 (Fri, 28, Sept)
Lecture 9 (Mon, 1 Oct)
Lecture 10 (Wed, 3 Oct)
Lecture 11 (Fri., 5 Oct.)
Lecture 12 (Wed., 10 Oct.)
Lecture 13 (Fri., 12 Oct.)
Lecture 14 (Mon, 15 Oct.)
Lecture 15 (Wed., 17 Oct.)
Lecture 16 (Fri, 19 Oct.)
Class canceled Mon., 22 Oct
Lecture 17 (Wed., 24 Oct.)
Lecture 18 (Fri., 26 Oct.)
Lecture 19 (Mon., 29 Oct.)
Lecture 20 (Wed., 31 Oct.)
Quiz 2 - No notes (Fri., 2 Nov.)
Lecture 21 (Mon, 5 Nov.)
Lecture 22 (Wed., 7 Nov.)

Lecture 23 (Fri., 9 Nov.)

Tumor cell video
Gleevec video
No class (Mon., 12 Nov.)

Lecture 24 (Wed., 14 Nov.)

Boston Globe Article: "Contagious cancers"

Lecture 25 (Fri., 16 Nov.)

Reading for Monday: Is HIV Smarter Than We Are? (from the HHMI)

Good material for review: Anti-HIV Therapy "Short Course"

Video shown in class
Lecture 26 (Mon. 19 Nov.)
Lecture 27 (Wed. 21 Nov.) -- notes available for those who attended class, just ask.
Thanksgiving Break - No Lecture (Fri., 23 Nov.)

Lecture 28 (Mon., 26 Nov)

Vaccine Production May Fail in Flu Pandemic
(from NPR)

Pandemic Flu Spurs Race for New Vaccine Methods (from NPR)

Seasonal Flu (from the CDC)
Avian Flu (from the CDC)
Pandemic Flu (from the CDC)
Lecture 29 (Fri. 30 Nov.)

Lecture 30 (Mon., 3 Dec.)

Information on Huntington's Disease (from the NIH)

Lecture 31 (Wed., 5 Dec.)

Readings about personalized medicine...

23AndMe Will Decode Your DNA for $1,000. Welcome to the Age of Genomics from Wired (Dec 2007)

X games for scientists offers $10m top prize: Competition set up to find quicker, cheaper way to analyze DNA for new field of personalized medicine (from the Boston Globe, 4 Dec 2007)
Instructions for downloading Chemoffice (follow very carefully; use a wired internet connection for best results).
 
 
On-line Textbooks
ChemGuide (table of contents)

Structure of Atoms (intro)

Atomic Orbitals

Electronic Structure of Atoms

Bonding (intro)

Ionic Bonding

Covalent Bonding

Intermolecular Interactions

van der Walls Interactions

hydrogen bonding

Stereoisomers ("handness")

for sp2 C's (double bonds)

for sp3 C's

Functional Groups

Hydroxyl Groups (alcohols)

Carbonyl Groups (aldhydes and ketones)

Amino Groups (amines)

Carboxylic Acids
 
Protein Structure
 
 
 
Resources for Case Studies
Gleevec Glory Days from HHMI (pdf version)
The Molecular Basis of Cancer
A Tale of Taxol

Mother Nature and the great influenza pandemic.
Oxford, John S. and Lambkin, Robert
Biologist; Aug 2005, Vol. 52 Issue 4, p211-212.

Link to pdf file.

AIDS/HIV Readings

Anti-HIV Therapy "Short Course" (view on-line)
Is HIV Smarter Than We Are? (from the HHMI)

NPR Stories on Flu Vaccine

Monday, 5 Dec -- Vaccine Production May Fail in Flu Pandemic

Tuesday, 6 Dec -- Pandemic Flu Spurs Race for New Vaccine Methods

 

Can I Get Personal from BioIT World (Mar 2007)
Other Material