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Lecture 17

Wednesday, October 24, 2007<= /p>

10:13 AM

 

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The Lego Exercise…

 

Before you is a structure which represents the surface of a protein…

 

Red indicat= es an area of positive charge

 

Blue indica= tes an area of negative charge

 

Yellow indi= cates a hydrogen bond donor

 

Black indic= ates a hydrogen bond acceptor

 

White indic= ates area that are nonpolar

 

Thus red is complementary to blue (= i.e. "opposites attract", yellow complementary to black and white with itself (i.e. "like dissolves like")

 

Your assignment is to design and bu= ild a "drug" which fits the surface you have been given.

 

You will be asked to explain and de= fend your decisions at the end of class.

 

 

 

Created with Microsoft Office OneNo= te 2003
One place for all your notes

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