MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C80CC8.CEBA0870" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C80CC8.CEBA0870 Content-Location: file:///C:/F1540253/Lecture_13.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="utf-8"

Thursday, October 11, 2007

5:24 PM

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Lunesta -- package insert: http://www.l= unesta.com/PostedApprovedLabelingText.pdf

LUNESTA (eszopiclone) is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class. The chemical name of eszopiclone is (+)-(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b] pyrazin-5-yl 4-methylpiperazine-1-carboxylate. Its molecular weight is 388.= 81, and its empirical formula is C17H17ClN6O3. Eszopiclone has a single chiral center with an (S )-configuration. It has the following

chemical structure:

Eszopiclone is a white to light-yel= low crystalline solid. Eszopiclone is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer (pH 3.2).

Eszopiclone is formulated as film-c= oated tablets for oral administration. LUNESTA tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titani= um dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.

Created with Microsoft Office OneNo= te 2003
One place for all your notes

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